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Original research articles (selected)
Inflammatory ER stress responses dictate the immunopathogenic progression of systemic candidiasis.
Awasthi D, Chopra S, Cho BA, Emmanuelli A, Sandoval TA, Hwang SM, Chae CS, Salvagno C, Tan C, Vasquez-Urbina L, Fernandez Rodriguez JJ, Santagostino SF, Iwawaki T, Romero-Sandoval EA, Crespo MS, Morales DK, Iliev ID, Hohl TM, Cubillos-Ruiz JR.
J Clin Invest. 2023 Jul 11. pii: e167359. doi: 10.1172/JCI167359. [Epub ahead of print]
Tumor-intrinsic IRE1α signaling controls protective immunity in lung cancer.
Crowley MJP, Bhinder B, Markowitz GJ, Martin M, Verma A, Sandoval TA, Chae CS, Yomtoubian S, Hu Y, Chopra S, Tavarez DA, Giovanelli P, Gao D, McGraw TE, Altorki NK, Elemento O, Cubillos-Ruiz JR*, Mittal V.*
Nat Commun. 2023 Jan 9;14(1):120. doi: 10.1038/s41467-022-35584-9. *Corresponding authors.
Chronic activation of pDCs in autoimmunity is linked to dysregulated ER stress and metabolic responses.
Chaudhary V, Ah Kioon MD, Hwang SM, Mishra B, Lakin K, Kirou KA, Zhang-Sun J, Wiseman RL, Spiera RF, Crow MK, Gordon JK, Cubillos-Ruiz JR, Barrat FJ.
J Exp Med. 2022 Nov 7;219(11). pii: e20221085. doi: 10.1084/jem.20221085. Epub 2022 Sep 2.
High-Fat Diet-Induced Obesity Alters Dendritic Cell Homeostasis by Enhancing Mitochondrial Fatty Acid Oxidation.
Chen IC, Awasthi D, Hsu CL, Song M, Chae CS, Dannenberg AJ, Cubillos-Ruiz JR.
J Immunol. 2022 Jul 1;209(1):69-76. doi: 10.4049/jimmunol.2100567. Epub 2022 Jun 13.
Tumor-Derived Lysophosphatidic Acid Blunts Protective Type I Interferon Responses in Ovarian Cancer.
Chae CS, Sandoval TA, Hwang SM, Park ES, Giovanelli P, Awasthi D, Salvagno C, Emmanuelli A, Tan C, Chaudhary V, Casado J, Kossenkov AV, Song M, Barrat FJ, Holcomb K, Romero-Sandoval EA, Zamarin D, Pépin D, D’Andrea AD, Färkkilä A, Cubillos-Ruiz JR.
Cancer Discov. 2022 Aug 5;12(8):1904-1921. doi: 10.1158/2159-8290.CD-21-1181.
Senescence induction dictates response to chemo- and immunotherapy in preclinical models of ovarian cancer.
Paffenholz SV, Salvagno C, Ho YJ, Limjoco M, Baslan T, Tian S, Kulick A, de Stanchina E, Wilkinson JE, Barriga FM, Zamarin D, Cubillos-Ruiz JR, Leibold J, Lowe SW.
Proc Natl Acad Sci U S A. 2022 Feb 1;119(5). pii: e2117754119. doi: 10.1073/pnas.2117754119.
BTN3A1 governs antitumor responses by coordinating αβ and γδ T cells.
Payne KK, Mine JA, Biswas S, Chaurio RA, Perales-Puchalt A, Anadon CM, Costich TL, Harro CM, Walrath J, Ming Q, Tcyganov E, Buras AL, Rigolizzo KE, Mandal G, Lajoie J, Ophir M, Tchou J, Marchion D, Luca VC, Bobrowicz P, McLaughlin B, Eskiocak U, Schmidt M, Cubillos-Ruiz JR, Rodriguez PC, Gabrilovich DI, Conejo-Garcia JR.
Science. 2020 Aug 21;369(6506):942-949. doi: 10.1126/science.aay2767.
The Unfolded Protein Response Mediator PERK Governs Myeloid Cell-Driven Immunosuppression in Tumors through Inhibition of STING Signaling.
Mohamed E, Sierra RA, Trillo-Tinoco J, Cao Y, Innamarato P, Payne KK, de Mingo Pulido A, Mandula J, Zhang S, Thevenot P, Biswas S, Abdalla SK, Costich TL, Hänggi K, Anadon CM, Flores ER, Haura EB, Mehrotra S, Pilon-Thomas S, Ruffell B, Munn DH, Cubillos-Ruiz JR, Conejo-Garcia JR, Rodriguez PC.
Immunity. 2020 Apr 14;52(4):668-682.e7. doi: 10.1016/j.immuni.2020.03.004.
IRE1α-XBP1 signaling in leukocytes controls prostaglandin biosynthesis and pain.
Chopra S, Giovanelli P, Alvarado-Vazquez PA, Alonso S, Song M, Sandoval TA, Chae CS, Tan C, Fonseca MM, Gutierrez S, Jimenez L, Subbaramaiah K, Iwawaki T, Kingsley PJ, Marnett LJ, Kossenkov AV, Crespo MS, Dannenberg AJ, Glimcher LH, Romero-Sandoval EA, Cubillos-Ruiz JR.
Science. 2019 Jul 19;365(6450). pii: eaau6499. doi: 10.1126/science.aau6499.
Article highlighted by: [Avril T & Chevet E. “Stress Signaling in Pain Control”. Science 2019 Jul 19;365(6450):224-225. doi: 10.1126/science.aay2721]
Somatic mutations and cell identity linked by Genotyping of Transcriptomes.
Nam AS, Kim KT, Chaligne R, Izzo F, Ang C, Taylor J, Myers RM, Abu-Zeinah G, Brand R, Omans ND, Alonso A, Sheridan C, Mariani M, Dai X, Harrington E, Pastore A, Cubillos-Ruiz JR, Tam W, Hoffman R, Rabadan R, Scandura JM, Abdel-Wahab O, Smibert P, Landau DA.
Nature. 2019 Jul;571(7765):355-360. doi: 10.1038/s41586-019-1367-0. Epub 2019 Jul 3.
IRE1α-XBP1 controls T cell function in ovarian cancer by regulating mitochondrial activity.
Song M, Sandoval TA, Chae CS, Chopra S, Tan C, Rutkowski MR, Raundhal M, Chaurio RA, Payne KK, Konrad C, Bettigole SE, Shin HR, Crowley MJP, Cerliani JP, Kossenkov AV, Motorykin I, Zhang S, Manfredi G, Zamarin D, Holcomb K, Rodriguez PC, Rabinovich GA, Conejo-Garcia JR, Glimcher LH, Cubillos-Ruiz JR.
Nature. 2018 Oct;562(7727):423-428. doi: 10.1038/s41586-018-0597-x. Epub 2018 Oct 10.
Article highlighted by: [Lopez-Soto A and Kroemer, G. “Cancer-induced Endoplasmic Reticulum Stress in T cells Subverts Immunosurveillance”. Cell Metabolism (Dec, 2018)] [Research Highlights in Nature Reviews Immunol. (Dec, 2018): “Stress management in T cells”] [Cancer Discovery (Oct, 2018) “IRE1α–XBP1 Suppresses the Antitumor Activity of T Cells”]
Endoplasmic Reticulum Stress Sensor IRE1α Enhances IL-23 Expression by Human Dendritic Cells.
Márquez S, Fernández JJ, Terán-Cabanillas E, Herrero C, Alonso S, Azogil A, Montero O, Iwawaki T, Cubillos-Ruiz JR, Fernández N, Crespo MS.
Front Immunol. 2017 Jun 19;8:639. doi: 10.3389/fimmu.2017.00639. eCollection 2017.
ER Stress Sensor XBP1 Controls Anti-tumor Immunity by Disrupting Dendritic Cell Homeostasis.
Cubillos-Ruiz JR, Silberman PC, Rutkowski MR, Chopra S, Perales-Puchalt A, Song M, Zhang S, Bettigole SE, Gupta D, Holcomb K, Ellenson LH, Caputo T, Lee AH, Conejo-Garcia JR, Glimcher LH.
Cell. 2015 Jun 18;161(7):1527-38. doi: 10.1016/j.cell.2015.05.025. Epub 2015 Jun 11.
Article highlighted by: [Merad M.& Salmon H; News and Views in Nature 523, 294–295 (2015): “Cancer: A dendritic-cell brake on antitumour immunity”] [Research Highlights in Nature Reviews Immunol. 15 (2015): “Stressed DCs can’t handle T cells”] [Highlighted in Cancer Discovery 5 (2015): “The ER Stress Factor XBP1 Inhibits Antitumor Immune Responses”] [Garris C & Pittet MJ. “ER Stress in Dendritic Cells Promotes Cancer”. Preview on Cubillos-Ruiz et al., Cell. 161: 1527–1538] [Maj T & Zou W; Research Highlight in Cell Research: 31 July 2015 doi: 10.1038/cr.2015.93 “Dendritic cells are stressed out in tumor’]
Commissioned reviews (selected)
Control of immune cell function by the unfolded protein response.
Di Conza G, Ho PC, Cubillos-Ruiz JR, Huang SC.
Nat Rev Immunol. 2023 Feb 8. doi: 10.1038/s41577-023-00838-0. [Epub ahead of print] Review.
Decoding endoplasmic reticulum stress signals in cancer cells and antitumor immunity.
Salvagno C, Mandula JK, Rodriguez PC, Cubillos-Ruiz JR.
Trends Cancer. 2022 Nov;8(11):930-943. doi: 10.1016/j.trecan.2022.06.006. Epub 2022 Jul 8. Review.
Engineered bacteria recycle tumor metabolic waste to boost immunotherapy.
Cubillos-Ruiz JR, Cubillos-Ruiz A.
Cell Host Microbe. 2021 Dec 8;29(12):1725-1727. doi: 10.1016/j.chom.2021.11.008.
Optineurin Guards IFNγ Signaling in Cancer Cells.
Salvagno C, Cubillos-Ruiz JR.
Cancer Discov. 2021 Jul;11(7):1623-1625. doi: 10.1158/2159-8290.CD-21-0362.
Endoplasmic reticulum stress signals in the tumour and its microenvironment.
Chen X, Cubillos-Ruiz JR.
Nat Rev Cancer. 2021 Feb;21(2):71-88. doi: 10.1038/s41568-020-00312-2. Epub 2020 Nov 19. Review.
The impact of endoplasmic reticulum stress responses in dendritic cell immunobiology.
Salvagno C, Cubillos-Ruiz JR.
Int Rev Cell Mol Biol. 2019;349:153-176. doi: 10.1016/bs.ircmb.2019.08.004. Epub 2019 Sep 11. Review.
Dendritic Cell Metabolism and Function in Tumors.
Giovanelli P, Sandoval TA, Cubillos-Ruiz JR.
Trends Immunol. 2019 Aug;40(8):699-718. doi: 10.1016/j.it.2019.06.004. Epub 2019 Jul 10. Review.
Endoplasmic Reticulum Stress Responses in Intratumoral Immune Cells: Implications for Cancer Immunotherapy.
Song M, Cubillos-Ruiz JR.
Trends Immunol. 2019 Feb;40(2):128-141. doi: 10.1016/j.it.2018.12.001. Epub 2019 Jan 3. Review.
Dendritic cell rehab: new strategies to unleash therapeutic immunity in ovarian cancer.
Chae CS, Teran-Cabanillas E, Cubillos-Ruiz JR.
Cancer Immunol Immunother. 2017 Aug;66(8):969-977. doi: 10.1007/s00262-017-1958-2. Epub 2017 Feb 18.
Tumorigenic and Immunosuppressive Effects of Endoplasmic Reticulum Stress in Cancer.
Cubillos-Ruiz JR, Bettigole SE, Glimcher LH.
Cell. 2017 Feb 9;168(4):692-706. doi: 10.1016/j.cell.2016.12.004. Review.
Unfolding anti-tumor immunity: ER stress responses sculpt tolerogenic myeloid cells in cancer.
Cubillos-Ruiz JR, Mohamed E, Rodriguez PC.
J Immunother Cancer. 2017 Jan 17;5:5. doi: 10.1186/s40425-016-0203-4. eCollection 2017. Review.
Targeting abnormal ER stress responses in tumors: A new approach to cancer immunotherapy.
Cubillos-Ruiz JR, Glimcher LH.
Oncoimmunology. 2015 Oct 29;5(3):e1098802. eCollection 2016 Mar.
Molecular Pathways: Immunosuppressive Roles of IRE1α-XBP1 Signaling in Dendritic Cells of the Tumor Microenvironment.
Cubillos-Ruiz JR, Bettigole SE, Glimcher LH.
Clin Cancer Res. 2016 May 1;22(9):2121-6. doi: 10.1158/1078-0432.CCR-15-1570. Epub 2016 Mar 15. Review.